People / Maguire Laboratory

Jamie Maguire, Ph.D.
Assistant Professor (effective January 1, 2010)

Currently at University of California, Los Angeles (UCLA)
Los Angeles, CA
Phone: (310) 206-3484
jamiemag@ucla.edu

Search for recent publications by Jamie Maguire

Research Interests

GABA_A receptors (GABA_ARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABA_ARs are dynamically regulated by a number of pathological (e.g. epilepsy) and physiological (e.g. pregnancy) conditions, which result in changes in neuronal excitability. Our lab focuses on investigating how dysfunction in GABA_AR regulation may play an important role in the pathophysiology of neurological and neuropsychiatric disorders, such as epilepsy, anxiety disorders, and depression. Employing a wide range of techniques, including electrophysiology, biochemistry and behavioral approaches, we seek to understand the pathogenesis of these disorders.

For more information, please see: www.maguirelab.com.

Lab Members

To join the Maguire lab at the research technician or postdoctoral level, please send a cover letter describing research interests, curriculum vitae, and names of three references to jamiemag@gmail.com.  Preferred experience includes: behavioral analysis of rodents, immunohistochemical techniques, and/or electrophysiology.

Selected Publications

Maguire, J.L.and Mody, I. (2009) Steroid hormone fluctuations and GABA_AR plasticity. Psychoneuroendocrinology. Epub ahead of print.

Maguire, J.L., Ferando, I., Simonsen, C., and Mody, I. (2009) Excitability changes related to GABA_A receptorplasticity during pregnancy. J Neurosci.;29 9592-9601.

Maguire, J.L.and Mody, I.  (2008)  GABA_A Receptor Plasticity during Pregnancy: Relevance to Postpartum Depression.  Neuron 59(2): 207 – 213.

Maguire, J.L. and Mody, I.  (2007)  Neurosteroid Synthesis-Mediated Regulation of GABA_A Receptors: Relevance to Ovarian Cycle and Stress.  J Neurosci.  27(9):2155–2162.

Maguire J, Klaassen A, Glykys J, Labarca C, Mody I, Boulter J. (2006) Seizures and enhanced cortical GABAergic inhibition in two mouse models of human autosomal dominant nocturnal frontal lobe epilepsy.  Proc Natl Acad Sci USA. 103(50):19152-19157.

Maguire, J.L., Stell, B.M., Rafizadeh, M., and Mody, I.  (2005)  Ovarian cycle-linked changes in GABA_A receptors mediating tonic inhibition alter seizure susceptibility and anxiety.  Nature Neurosci  Jun;8(6):797-804.